Assay Detail
Functional
CHEMBL4844082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of 5-FU resistance against human SW620/5-FU cells assessed as inhibition of cell proliferation measured after 72 hrs in presence of 5-FU by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW620/5-FU |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2 antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 4.96 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871603 | — | — | 1 | 6.68 |
| CHEMBL4858074 | — | — | 1 | 5.60 |
| CHEMBL4874765 | — | — | 1 | 5.29 |
| CHEMBL4861095 | — | — | 1 | 5.21 |
| CHEMBL4853969 | — | — | 1 | 5.09 |
| CHEMBL4879008 | — | — | 1 | 5.08 |
| CHEMBL4878547 | — | — | 1 | 5.03 |
| CHEMBL4852333 | — | — | 1 | 5.02 |
| CHEMBL4858060 | — | — | 1 | 4.93 |
| CHEMBL4847029 | — | — | 1 | 4.91 |
| CHEMBL4846520 | — | — | 1 | 4.85 |
| CHEMBL4865240 | — | — | 1 | 4.51 |
| CHEMBL4862332 | — | — | 1 | 4.50 |
| CHEMBL4846434 | — | — | 1 | 4.32 |
| CHEMBL1368758 | — | — | 1 | 4.23 |
| CHEMBL4850828 | — | — | 1 | 4.17 |
| CHEMBL4855889 | — | — | 1 | - |
| CHEMBL4866321 | — | — | 1 | - |
| CHEMBL4870233 | — | — | 1 | - |
| CHEMBL4858648 | — | — | 1 | - |
| CHEMBL4855447 | — | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871603 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4858074 | — | EC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4874765 | — | EC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL4861095 | — | EC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL4853969 | — | EC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL4879008 | — | EC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL4878547 | — | EC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL4852333 | — | EC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL4858060 | — | EC50 | = | 11720.0 | nM | 4.93 |
| CHEMBL4847029 | — | EC50 | = | 12240.0 | nM | 4.91 |
| CHEMBL4846520 | — | EC50 | = | 14210.0 | nM | 4.85 |
| CHEMBL4865240 | — | EC50 | = | 31150.0 | nM | 4.51 |
| CHEMBL4862332 | — | EC50 | = | 31950.0 | nM | 4.50 |
| CHEMBL4846434 | — | EC50 | = | 48250.0 | nM | 4.32 |
| CHEMBL1368758 | — | EC50 | = | 58580.0 | nM | 4.23 |
| CHEMBL4850828 | — | EC50 | = | 67210.0 | nM | 4.17 |
| CHEMBL4855889 | — | EC50 | = | 548250.0 | nM | - |
| CHEMBL4866321 | — | EC50 | = | 234140.0 | nM | - |
| CHEMBL4870233 | — | EC50 | = | 122240.0 | nM | - |
| CHEMBL4858648 | — | EC50 | = | 528120.0 | nM | - |
| CHEMBL4855447 | — | EC50 | = | 436270.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | EC50 | > | 1000000.0 | nM | - |