Assay Detail
Binding
CHEMBL4844257
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Inhibition of human recombinant BACE-1 expressed in Escherichia coli using panvera peptide as a substrate incubated for 1 hr by fluorescence analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.44 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3304306 | — | — | 1 | 5.82 |
| CHEMBL4859103 | — | — | 1 | 5.57 |
| CHEMBL164 | MYRICETIN | — | 1 | 5.38 |
| CHEMBL4862716 | — | — | 1 | 4.97 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
| CHEMBL345124 | PROPIDIUM | — | 1 | - |
| CHEMBL3545559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3304306 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4859103 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL164 | MYRICETIN | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL4862716 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - | |
| CHEMBL345124 | PROPIDIUM | IC50 | - | — | - | |
| CHEMBL3545559 | — | IC50 | - | — | - |