Assay Detail
Functional
CHEMBL4844305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H23 cells assessed as reduction in cell viability after 4 days by CellTiter-Glo assay
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H23 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.59 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866800 | — | — | 1 | 7.58 |
| CHEMBL4865418 | — | — | 1 | 7.38 |
| CHEMBL4871231 | — | — | 1 | 7.27 |
| CHEMBL4868683 | — | — | 1 | 7.25 |
| CHEMBL4853285 | — | — | 1 | 7.24 |
| CHEMBL4862622 | — | — | 1 | 7.19 |
| CHEMBL4849097 | — | — | 1 | 7.09 |
| CHEMBL4871593 | — | — | 1 | 6.99 |
| CHEMBL4875570 | — | — | 1 | 6.98 |
| CHEMBL4856253 | — | — | 1 | 6.96 |
| CHEMBL4874546 | — | — | 1 | 6.94 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 6.91 |
| CHEMBL4861383 | — | — | 1 | 6.89 |
| CHEMBL4867211 | — | — | 1 | 6.82 |
| CHEMBL4857841 | — | — | 1 | 6.75 |
| CHEMBL4853973 | — | — | 1 | 6.73 |
| CHEMBL4876612 | — | — | 1 | 6.73 |
| CHEMBL4865963 | — | — | 1 | 6.73 |
| CHEMBL4861351 | — | — | 1 | 6.67 |
| CHEMBL4867107 | — | — | 1 | 6.65 |
| CHEMBL4856035 | — | — | 1 | 6.57 |
| CHEMBL4847705 | — | — | 1 | 6.56 |
| CHEMBL4875039 | — | — | 1 | 6.56 |
| CHEMBL4871803 | — | — | 1 | 6.50 |
| CHEMBL4879157 | — | — | 1 | 5.94 |
| CHEMBL4861168 | — | — | 1 | 5.85 |
| CHEMBL4874090 | — | — | 1 | 5.81 |
| CHEMBL4853185 | — | — | 2 | 5.64 |
| CHEMBL4847051 | — | — | 1 | 5.47 |
| CHEMBL4877772 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866800 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4865418 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4871231 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4868683 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4853285 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4862622 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4849097 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4871593 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4875570 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4856253 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4874546 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL4861383 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4867211 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4857841 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4876612 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4865963 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4853973 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4861351 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL4867107 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4856035 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4847705 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL4875039 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4871803 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL4879157 | — | IC50 | = | 1139.0 | nM | 5.94 |
| CHEMBL4861168 | — | IC50 | = | 1425.0 | nM | 5.85 |
| CHEMBL4874090 | — | IC50 | = | 1533.0 | nM | 5.81 |
| CHEMBL4853185 | — | IC50 | = | 2297.0 | nM | 5.64 |
| CHEMBL4853185 | — | IC50 | = | 2524.0 | nM | 5.60 |
| CHEMBL4847051 | — | IC50 | = | 3363.0 | nM | 5.47 |
| CHEMBL4877772 | — | IC50 | = | 4725.0 | nM | 5.33 |
| CHEMBL4863657 | — | IC50 | = | 5783.0 | nM | 5.24 |