Assay Detail
Binding
CHEMBL4844509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5HT6R expressed in CHO-K1 cell membranes incubated for 1 hr by scintillation counter method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT<sub>6</sub> receptor with anti-aggregation properties against amyloid-beta and tau.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.47 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852099 | — | — | 1 | 10.00 |
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 9.52 |
| CHEMBL4863218 | — | — | 1 | 9.00 |
| CHEMBL4854972 | — | — | 1 | 8.77 |
| CHEMBL4864206 | — | — | 1 | 8.70 |
| CHEMBL4851595 | — | — | 1 | 8.70 |
| CHEMBL4847532 | — | — | 1 | 8.70 |
| CHEMBL4878383 | — | — | 1 | 8.52 |
| CHEMBL4878361 | — | — | 1 | 8.52 |
| CHEMBL4874513 | — | — | 1 | 8.46 |
| CHEMBL4868597 | — | — | 1 | 8.46 |
| CHEMBL4848231 | — | — | 1 | 8.15 |
| CHEMBL4850488 | — | — | 1 | 8.10 |
| CHEMBL4866788 | — | — | 1 | 8.10 |
| CHEMBL4877482 | — | — | 1 | 8.07 |
| CHEMBL4850051 | — | — | 1 | 8.00 |
| CHEMBL4847373 | — | — | 1 | 7.96 |
| CHEMBL4871964 | — | — | 1 | 7.92 |
| CHEMBL4850546 | — | — | 1 | 7.89 |
| CHEMBL4845823 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852099 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL93240 | METITEPINE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4863218 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4854972 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4864206 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4851595 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4847532 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4878383 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4878361 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4874513 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4868597 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4848231 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4850488 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4866788 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4877482 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL4850051 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4847373 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4871964 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4850546 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4845823 | — | Ki | = | 15.0 | nM | 7.82 |