Assay Detail
Binding
CHEMBL4844512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophotometric based Ellman's method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT<sub>6</sub> receptor with anti-aggregation properties against amyloid-beta and tau.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.85 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850546 | — | — | 1 | 8.07 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.96 |
| CHEMBL4850051 | — | — | 1 | 7.68 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.64 |
| CHEMBL4874513 | — | — | 1 | 7.24 |
| CHEMBL4877482 | — | — | 1 | 7.14 |
| CHEMBL4848231 | — | — | 1 | 6.52 |
| CHEMBL4878361 | — | — | 1 | 5.54 |
| CHEMBL4878383 | — | — | 1 | 5.37 |
| CHEMBL4847532 | — | — | 1 | 5.32 |
| CHEMBL4866788 | — | — | 1 | - |
| CHEMBL4850488 | — | — | 1 | - |
| CHEMBL4845823 | — | — | 1 | - |
| CHEMBL4854972 | — | — | 1 | - |
| CHEMBL4864206 | — | — | 1 | - |
| CHEMBL4868597 | — | — | 1 | - |
| CHEMBL4851595 | — | — | 1 | - |
| CHEMBL4852099 | — | — | 1 | - |
| CHEMBL4847373 | — | — | 1 | - |
| CHEMBL4863218 | — | — | 1 | - |
| CHEMBL4871964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850546 | — | IC50 | = | 8.42 | nM | 8.07 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4850051 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL95 | TACRINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4874513 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL4877482 | — | IC50 | = | 72.48 | nM | 7.14 |
| CHEMBL4848231 | — | IC50 | = | 303.1 | nM | 6.52 |
| CHEMBL4878361 | — | IC50 | = | 2869.0 | nM | 5.54 |
| CHEMBL4878383 | — | IC50 | = | 4236.0 | nM | 5.37 |
| CHEMBL4847532 | — | IC50 | = | 4841.0 | nM | 5.32 |
| CHEMBL4866788 | — | IC50 | - | — | - | |
| CHEMBL4850488 | — | IC50 | - | — | - | |
| CHEMBL4845823 | — | IC50 | - | — | - | |
| CHEMBL4854972 | — | IC50 | - | — | - | |
| CHEMBL4864206 | — | IC50 | = | 4467000.0 | nM | - |
| CHEMBL4868597 | — | IC50 | - | — | - | |
| CHEMBL4851595 | — | IC50 | - | — | - | |
| CHEMBL4852099 | — | IC50 | = | 6214000.0 | nM | - |
| CHEMBL4847373 | — | IC50 | - | — | - | |
| CHEMBL4863218 | — | IC50 | - | — | - | |
| CHEMBL4871964 | — | IC50 | - | — | - |