Assay Detail
Functional
CHEMBL4844612
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Growth inhibition of human VCaP cells assessed as cell viability by WST-8 assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | VCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.11 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854467 | — | — | 1 | 9.10 |
| CHEMBL4862569 | — | — | 1 | 8.96 |
| CHEMBL4870803 | — | — | 1 | 8.82 |
| CHEMBL4849315 | — | — | 1 | 8.74 |
| CHEMBL4867888 | — | — | 1 | 8.68 |
| CHEMBL4846253 | — | — | 1 | 8.57 |
| CHEMBL4849497 | — | — | 1 | 8.37 |
| CHEMBL4872965 | — | — | 1 | 8.29 |
| CHEMBL4850138 | — | — | 1 | 8.17 |
| CHEMBL4861698 | — | — | 1 | 8.10 |
| CHEMBL4856700 | — | — | 1 | 8.01 |
| CHEMBL4854303 | — | — | 1 | 7.78 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | 1.0 | 1 | 7.52 |
| CHEMBL4861621 | — | — | 1 | 7.21 |
| CHEMBL4870470 | — | — | 1 | 7.08 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 6.41 |
| CHEMBL4876553 | — | — | 1 | - |
| CHEMBL4875549 | — | — | 1 | - |
| CHEMBL4852233 | — | — | 1 | - |
| CHEMBL4873439 | — | — | 1 | - |
| CHEMBL4846811 | — | — | 1 | - |
| CHEMBL4853200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854467 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4862569 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4870803 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4849315 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4867888 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4846253 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4849497 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4872965 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4850138 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4861698 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4856700 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4854303 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL4861621 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4870470 | — | IC50 | = | 83.5 | nM | 7.08 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL4876553 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4875549 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4852233 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4873439 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4846811 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4853200 | — | IC50 | > | 1000.0 | nM | - |