Assay Detail
Binding
CHEMBL4844699
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Inhibition of human CA12 measured after 15 mins by stopped flow carbon dioxide anhydrase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.45 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4853109 | — | — | 1 | 7.34 |
| CHEMBL4877944 | — | — | 1 | 7.24 |
| CHEMBL4875528 | — | — | 1 | 6.46 |
| CHEMBL4869264 | — | — | 1 | 6.22 |
| CHEMBL4868916 | — | — | 1 | 6.14 |
| CHEMBL4870002 | — | — | 1 | 4.86 |
| CHEMBL4849692 | — | — | 1 | 4.84 |
| CHEMBL4854547 | — | — | 1 | 4.78 |
| CHEMBL4869758 | — | — | 1 | - |
| CHEMBL4872991 | — | — | 1 | - |
| CHEMBL4877790 | — | — | 1 | - |
| CHEMBL4846928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4853109 | — | Ki | = | 45.6 | nM | 7.34 |
| CHEMBL4877944 | — | Ki | = | 57.5 | nM | 7.24 |
| CHEMBL4875528 | — | Ki | = | 344.8 | nM | 6.46 |
| CHEMBL4869264 | — | Ki | = | 602.9 | nM | 6.22 |
| CHEMBL4868916 | — | Ki | = | 721.2 | nM | 6.14 |
| CHEMBL4870002 | — | Ki | = | 13900.0 | nM | 4.86 |
| CHEMBL4849692 | — | Ki | = | 14400.0 | nM | 4.84 |
| CHEMBL4854547 | — | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL4869758 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4872991 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4877790 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4846928 | — | Ki | > | 100000.0 | nM | - |