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Assay Detail

CHEMBL4844708

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type 4T1
Confidence 1 — Organism
Curated By Autocuration

Target

4T1 (CHEMBL612589)
Type CELL-LINE
Organism Mus musculus

Publication

Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer.
Xu C, Xiao Z, Wang J, Lai H, Zhang T, Guan Z, Xia M, Chen M, Ren L, He Y, Gao Y, Zhao C.
J Med Chem (2021) 64 : 13312 -13326
PubMed 34506134 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 5.51 6.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4869036 1 6.12
CHEMBL4870989 1 6.11
CHEMBL4854663 1 6.09
CHEMBL4857061 1 6.05
CHEMBL4866635 1 5.98
CHEMBL4847191 1 5.83
CHEMBL4858593 1 5.71
CHEMBL4875408 1 5.71
CHEMBL4847405 1 5.70
CHEMBL4866818 1 5.68
CHEMBL4870519 1 5.67
CHEMBL4851930 1 5.66
CHEMBL4876863 1 5.64
CHEMBL4870663 1 5.63
CHEMBL1499544 1 5.60
CHEMBL4868840 1 5.53
CHEMBL4864795 1 5.49
CHEMBL4747331 1 5.43
CHEMBL4852206 1 5.35
CHEMBL4848813 1 5.33
CHEMBL4857142 1 5.31
CHEMBL4850327 1 5.23
CHEMBL4848626 1 5.19
CHEMBL4858640 1 5.04
CHEMBL4877321 1 5.03
CHEMBL4857735 1 5.03
CHEMBL4846939 1 5.03
CHEMBL4846227 1 5.01
CHEMBL4854607 1 5.00
CHEMBL4858099 1 4.99

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4869036 IC50 = 750.0 nM 6.12
CHEMBL4870989 IC50 = 780.0 nM 6.11
CHEMBL4854663 IC50 = 810.0 nM 6.09
CHEMBL4857061 IC50 = 890.0 nM 6.05
CHEMBL4866635 IC50 = 1040.0 nM 5.98
CHEMBL4847191 IC50 = 1480.0 nM 5.83
CHEMBL4858593 IC50 = 1930.0 nM 5.71
CHEMBL4875408 IC50 = 1940.0 nM 5.71
CHEMBL4847405 IC50 = 1990.0 nM 5.70
CHEMBL4866818 IC50 = 2070.0 nM 5.68
CHEMBL4870519 IC50 = 2150.0 nM 5.67
CHEMBL4851930 IC50 = 2170.0 nM 5.66
CHEMBL4876863 IC50 = 2310.0 nM 5.64
CHEMBL4870663 IC50 = 2350.0 nM 5.63
CHEMBL1499544 IC50 = 2520.0 nM 5.60
CHEMBL4868840 IC50 = 2960.0 nM 5.53
CHEMBL4864795 IC50 = 3220.0 nM 5.49
CHEMBL4747331 IC50 = 3690.0 nM 5.43
CHEMBL4852206 IC50 = 4470.0 nM 5.35
CHEMBL4848813 IC50 = 4630.0 nM 5.33
CHEMBL4857142 IC50 = 4920.0 nM 5.31
CHEMBL4850327 IC50 = 5860.0 nM 5.23
CHEMBL4848626 IC50 = 6470.0 nM 5.19
CHEMBL4858640 IC50 = 9210.0 nM 5.04
CHEMBL4877321 IC50 = 9300.0 nM 5.03
CHEMBL4857735 IC50 = 9300.0 nM 5.03
CHEMBL4846939 IC50 = 9430.0 nM 5.03
CHEMBL4846227 IC50 = 9720.0 nM 5.01
CHEMBL4854607 IC50 = 9910.0 nM 5.00
CHEMBL4858099 IC50 = 10240.0 nM 4.99