Assay Detail
Functional
CHEMBL4844740
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.06 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 7.28 |
| CHEMBL4870348 | — | — | 1 | 5.14 |
| CHEMBL4858329 | — | — | 1 | 5.12 |
| CHEMBL4846560 | — | — | 1 | 4.93 |
| CHEMBL4851752 | — | — | 1 | 4.91 |
| CHEMBL4863909 | — | — | 1 | 4.85 |
| CHEMBL4847792 | — | — | 1 | 4.70 |
| CHEMBL4876402 | — | — | 1 | 4.63 |
| CHEMBL4846776 | — | — | 1 | 4.61 |
| CHEMBL4874936 | — | — | 1 | 4.38 |
| CHEMBL4872229 | — | — | 1 | - |
| CHEMBL4864222 | — | — | 1 | - |
| CHEMBL4877972 | — | — | 1 | - |
| CHEMBL4867740 | — | — | 1 | - |
| CHEMBL4846661 | — | — | 1 | - |
| CHEMBL4863051 | — | — | 1 | - |
| CHEMBL4865669 | — | — | 1 | - |
| CHEMBL4858719 | — | — | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL4877890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4870348 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL4858329 | — | IC50 | = | 7570.0 | nM | 5.12 |
| CHEMBL4846560 | — | IC50 | = | 11850.0 | nM | 4.93 |
| CHEMBL4851752 | — | IC50 | = | 12440.0 | nM | 4.91 |
| CHEMBL4863909 | — | IC50 | = | 14010.0 | nM | 4.85 |
| CHEMBL4847792 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4876402 | — | IC50 | = | 23230.0 | nM | 4.63 |
| CHEMBL4846776 | — | IC50 | = | 24740.0 | nM | 4.61 |
| CHEMBL4874936 | — | IC50 | = | 42130.0 | nM | 4.38 |
| CHEMBL4872229 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4864222 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4877972 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4867740 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL4846661 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4863051 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL4865669 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL4858719 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | > | 150000.0 | nM | - |
| CHEMBL4877890 | — | IC50 | > | 150000.0 | nM | - |