Assay Detail
Functional
CHEMBL4844749
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Antiproliferative activity against human PLC-PRF-5 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PLC-PRF-5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.78 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.65 |
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 5.18 |
| CHEMBL4846776 | — | — | 1 | 4.83 |
| CHEMBL4874936 | — | — | 1 | 4.62 |
| CHEMBL4863909 | — | — | 1 | 4.53 |
| CHEMBL4870348 | — | — | 1 | 4.51 |
| CHEMBL4876402 | — | — | 1 | 4.47 |
| CHEMBL4858329 | — | — | 1 | 4.45 |
| CHEMBL4851752 | — | — | 1 | - |
| CHEMBL4846560 | — | — | 1 | - |
| CHEMBL4877972 | — | — | 1 | - |
| CHEMBL4858719 | — | — | 1 | - |
| CHEMBL4847792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL3545097 | SAPANISERTIB | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL4846776 | — | IC50 | = | 14870.0 | nM | 4.83 |
| CHEMBL4874936 | — | IC50 | = | 24040.0 | nM | 4.62 |
| CHEMBL4863909 | — | IC50 | = | 29620.0 | nM | 4.53 |
| CHEMBL4870348 | — | IC50 | = | 30540.0 | nM | 4.51 |
| CHEMBL4876402 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL4858329 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL4851752 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4846560 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4877972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4858719 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL4847792 | — | IC50 | > | 50000.0 | nM | - |