Assay Detail
Binding
CHEMBL4844752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin) using U-Light-4E-BP1 peptide as a substrate in the presence of ATP incubated for 30 mins by Lance ultra assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.15 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 9.19 |
| CHEMBL4870348 | — | — | 1 | 8.39 |
| CHEMBL4846560 | — | — | 1 | 8.12 |
| CHEMBL1081312 | — | — | 1 | 8.00 |
| CHEMBL4846776 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL4870348 | — | IC50 | = | 4.05 | nM | 8.39 |
| CHEMBL4846560 | — | IC50 | = | 7.67 | nM | 8.12 |
| CHEMBL1081312 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4846776 | — | IC50 | = | 92.3 | nM | 7.04 |