Assay Detail
Binding
CHEMBL4844756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC8 (unknown origin) using Ac-peptide as a substrate pretreated for 15 mins followed by substrate addition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.36 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4846560 | — | — | 1 | 6.64 |
| CHEMBL4870348 | — | — | 1 | 6.48 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.19 |
| CHEMBL4846776 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4846560 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL4870348 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 646.0 | nM | 6.19 |
| CHEMBL4846776 | — | IC50 | = | 733.0 | nM | 6.13 |