Assay Detail
ADMET
CHEMBL4844758
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Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.18 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 6.55 |
| CHEMBL4870348 | — | — | 1 | 5.09 |
| CHEMBL4846560 | — | — | 1 | 4.61 |
| CHEMBL4846776 | — | — | 1 | 4.46 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4870348 | — | IC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL4846560 | — | IC50 | = | 24810.0 | nM | 4.61 |
| CHEMBL4846776 | — | IC50 | = | 35080.0 | nM | 4.46 |
| CHEMBL98 | VORINOSTAT | IC50 | > | 50000.0 | nM | - |