Assay Detail
Binding
CHEMBL4845068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MGAT2 in mouse STC-1 cell based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | STC-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (CHEMBL2321630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.19 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3893594 | — | — | 1 | 9.20 |
| CHEMBL4878564 | — | — | 1 | 7.89 |
| CHEMBL3912712 | BMS-963272 | 1.0 | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3893594 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4878564 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3912712 | BMS-963272 | IC50 | = | 33.0 | nM | 7.48 |