Assay Detail
Binding
CHEMBL4845217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin) using Ac-peptide-AMC as substrate incubated for 1 hr by fluorescence method
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.30 | 9.30 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 9.30 |
| CHEMBL3774877 | — | — | 1 | - |
| CHEMBL4873929 | — | — | 1 | - |
| CHEMBL4861434 | — | — | 1 | - |
| CHEMBL4852612 | — | — | 1 | - |
| CHEMBL4866942 | — | — | 1 | - |
| CHEMBL4878408 | — | — | 1 | - |
| CHEMBL4866829 | — | — | 1 | - |
| CHEMBL4871714 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3774877 | — | Inhibition | - | % | - | |
| CHEMBL4873929 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4861434 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4852612 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4866942 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4878408 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4866829 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4871714 | — | IC50 | > | 10000.0 | nM | - |