Assay Detail
Binding
CHEMBL4845506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at muscarinic acetylcholine receptor in human CCRF-CEM cells assessed as inhibition of acetylcholine-induced calcium release preincubated for 25 mins followed by acetylcholine addition and monitered for 90 sec
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.33 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864332 | — | — | 1 | 6.08 |
| CHEMBL4862362 | — | — | 1 | 5.54 |
| CHEMBL4853570 | — | — | 1 | 5.19 |
| CHEMBL4875030 | — | — | 1 | 4.92 |
| CHEMBL4863276 | — | — | 1 | 4.91 |
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | - |
| CHEMBL3091687 | — | — | 1 | - |
| CHEMBL4849088 | — | — | 1 | - |
| CHEMBL4846946 | — | — | 1 | - |
| CHEMBL4857452 | — | — | 1 | - |
| CHEMBL4876951 | — | — | 1 | - |
| CHEMBL4858136 | — | — | 1 | - |
| CHEMBL4862509 | — | — | 1 | - |
| CHEMBL4877757 | — | — | 1 | - |
| CHEMBL4874526 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864332 | — | IC50 | = | 826.0 | nM | 6.08 |
| CHEMBL4862362 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4853570 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL4875030 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4863276 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL518924 | MAVORIXAFOR | IC50 | > | 33300.0 | nM | - |
| CHEMBL3091687 | — | IC50 | > | 8330.0 | nM | - |
| CHEMBL4849088 | — | IC50 | > | 16700.0 | nM | - |
| CHEMBL4846946 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL4857452 | — | IC50 | > | 16700.0 | nM | - |
| CHEMBL4876951 | — | IC50 | > | 16700.0 | nM | - |
| CHEMBL4858136 | — | IC50 | > | 16700.0 | nM | - |
| CHEMBL4862509 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL4877757 | — | IC50 | > | 5560.0 | nM | - |
| CHEMBL4874526 | — | IC50 | > | 16700.0 | nM | - |