Assay Detail
Binding
CHEMBL4880235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]-endothelin-3 binding to EDNRB
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe ABT-546
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.81 | 4.81 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 10082200 |
| Target protein type | Target protein type | - | — | Membranes prepared from CHO cells stably transfected with human EDNRA and EDNRB |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111612 | ABT-546 | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111612 | ABT-546 | IC50 | = | 15400.0 | nM | 4.81 |