Assay Detail
Binding
CHEMBL4881442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Bicochemical assay
2
Total Activities
2
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe BAY-678
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.70 | 7.70 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | Hydrolysis of the fluorogenic peptide substrate MeOSuc-AAPV-AMC |
| Assay publication | Assay publication | - | — | PMID: 26083237 |
| Target protein type | Target protein type | - | — | Human neutrophil elastase purified from blood neutrophils |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617968 | BAY-678 | — | 1 | 7.70 |
| CHEMBL4520674 | BAY-677 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617968 | BAY-678 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4520674 | BAY-677 | IC50 | > | 2000.0 | nM | - |