Assay Detail

CHEMBL4881481

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Binding

Biochemical ROCK2 assay

ChEMBL ↗

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Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Open DB target context

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Primary target Rho-associated protein kinase 2

CHEMBL2973

Anchored from Assay target.

Protein identity Rho-associated protein kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Data for DCP probe BAY-549

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.86	8.96

Assay Parameters

Parameter	Type	Value	Units	Text
Assay publication	Assay publication	-	—	PMID: 18973168

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1971943	BAY-549	—	1	8.96
CHEMBL4546802	BAY-4900	—	1	4.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1971943	BAY-549	IC50	=	1.1	nM	8.96
CHEMBL4546802	BAY-4900	IC50	=	17700.0	nM	4.75