Assay Detail

CHEMBL4882544

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Binding

HCVPV RNA replication Luciferase reporter assay, genotype 1a

ChEMBL ↗

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Target

NS3 protease (CHEMBL4296313) ↗

Open DB target context

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Primary target NS3 protease

CHEMBL4296313

Anchored from Assay target.

Protein identity NS3 protease

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepatitis C virus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

NS3 protease (CHEMBL4296313) ↗

Type	SINGLE PROTEIN
Organism	Hepacivirus C

Publication

Data for DCP probe BI-1230

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.34	8.34

Assay Parameters

Parameter	Type	Value	Units	Text
Additional information	Additional information	-	—	Huh7 cells, 72 h incubation
Assay publication	Assay publication	-	—	PMID: 12671967

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4588900	BI 1230	—	1	8.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4588900	BI 1230	EC50	=	4.6	nM	8.34