Assay Detail
Binding
CHEMBL4882585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Human Mast Cell degranulation
2
Total Activities
2
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Mast cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Data for DCP probe MRL-SYKi
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.42 | 7.42 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Target protein type | Target protein type | - | — | Differentiated primary human mast cells (HMC, AllCells, mPB-CD34+ precursor cells) |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3685796 | MRL-SYKi | — | 1 | 7.42 |
| CHEMBL4530401 | MRL-SYKi-NC | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3685796 | MRL-SYKi | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4530401 | MRL-SYKi-NC | IC50 | > | 10000.0 | nM | - |