Assay Detail
Binding
CHEMBL4882619
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Radioligand Binding Assay (CNR1)
2
Total Activities
2
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe MRL-650
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.12 | 8.12 |
| Inverse agonism | 1 | - | - |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | Measurement of the reduction in binding of [3H]CP-55940 (a hCB1r agonist) to recombinant human CB1r expressed in CHO cell membranes in the presence of the test compound |
| Assay publication | Assay publication | - | — | PMID: 16263284 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204232 | NAPHTHYRIDINONE | — | 1 | 8.12 |
| CHEMBL4578164 | MRL-CB1-NC | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204232 | NAPHTHYRIDINONE | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4578164 | MRL-CB1-NC | Inverse agonism | = | 32.5 | % | - |