Assay Detail
Binding
CHEMBL4883072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cold activation
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 8 (CHEMBL1075319) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe PF-05105679
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.32 | 6.32 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | The application of cold (10°C) causes a flux of Ca2+ across the cell membrane, which was measured by changes inintracellular fluorescence on a real-time PCR machine. |
| Assay publication | Assay publication | - | — | PMID: 25125580 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577885 | PF-05105679 | 1.0 | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577885 | PF-05105679 | IC50 | = | 480.0 | nM | 6.32 |