Assay Detail
Binding
CHEMBL4883620
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Time-resolved fluorescence energy transfer (TR-FRET) with MCL1
3
Total Activities
3
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe A-1211212
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.41 | 5.70 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 25313317 |
| Target protein length | Target protein length | - | — | full length |
| Target protein type | Target protein type | - | — | recombinant protein (GST-Mcl-1) |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342191 | A-1107969 | — | 1 | 5.70 |
| CHEMBL4228713 | A-1211212 | — | 1 | 5.69 |
| CHEMBL3342332 | A-1155463 | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342191 | A-1107969 | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4228713 | A-1211212 | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL3342332 | A-1155463 | IC50 | = | 14000.0 | nM | 4.85 |