Assay Detail
Binding
CHEMBL4884600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TR-FRET (human RIPK1)
3
Total Activities
3
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe TP-030-1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.65 | 9.37 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 29485864 |
| Target protein length | Target protein length | - | — | AA 1-375 |
| Target protein type | Target protein type | - | — | GST-His-RIPK1(1−375): BaculoDirect baculovirus expression system |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4549667 | TP-030-2 | — | 1 | 9.37 |
| CHEMBL4088216 | TP-030-1 | — | 1 | 8.41 |
| CHEMBL4097778 | TP-030n | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4549667 | TP-030-2 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL4088216 | TP-030-1 | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL4097778 | TP-030n | Ki | = | 6900.0 | nM | 5.16 |