Assay Detail
Binding
CHEMBL4885538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cellular mechanistic assay – BCAA measurement (U-87-MG cells)
2
Total Activities
2
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Branched-chain-amino-acid aminotransferase, cytosolic (CHEMBL4679) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe BAY-069
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.83 | 6.45 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Target protein type | Target protein type | - | — | U-87-MG (high BCAT1 expressing) cells |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4551635 | BAY-069 | — | 1 | 6.45 |
| CHEMBL4572210 | BAY-771 | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4551635 | BAY-069 | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL4572210 | BAY-771 | IC50 | = | 6200.0 | nM | 5.21 |