Assay Detail
Binding
CHEMBL4886193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SPA with mouse PDE10A
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL1795126) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Data for DCP probe JNJ-42396302
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 7.96 | 7.96 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | [3H]cAMP substrate |
| Target protein type | Target protein type | - | — | Recombinant mouse protein expressed in Sf9 cells (using baculovirus expression system) |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180408 | JNJ-42396302 | 1.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180408 | JNJ-42396302 | Ki | = | 11.0 | nM | 7.96 |