Assay Detail
Binding
CHEMBL4886504
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Time-resolved fluorescence energy transfer (TR-FRET) measuring acetylation of a biotinylated histone H4 peptide (EP300)
2
Total Activities
2
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe A-485
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.01 | 8.01 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 28953875 |
| Target protein length | Target protein length | - | — | BHC (bromodomain-HAT-C/H3) domain |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4282264 | A-485 | — | 1 | 8.01 |
| CHEMBL4536197 | A-486 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4282264 | A-485 | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4536197 | A-486 | IC50 | > | 10000.0 | nM | - |