Assay Detail

CHEMBL4887100

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Binding

Binding assay (PTK2)

ChEMBL ↗

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Target

Focal adhesion kinase 1 (CHEMBL2695) ↗

Open DB target context

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Primary target Focal adhesion kinase 1

CHEMBL2695

Anchored from Assay target.

Protein identity Focal adhesion kinase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Focal adhesion kinase 1 (CHEMBL2695) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Data for DCP probe PF-04554878

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.92	9.70

Assay Parameters

Parameter	Type	Value	Units	Text
Target protein length	Target protein length	-	—	kinase domain
Target protein type	Target protein type	-	—	human recombinant

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3137331	DEFACTINIB	3.0	1	9.70
CHEMBL4518706	PF-00911705	—	1	6.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3137331	DEFACTINIB	IC50	=	0.2	nM	9.70
CHEMBL4518706	PF-00911705	IC50	=	721.0	nM	6.14