Assay Detail

CHEMBL4887673

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Binding

Angiotensin II formation by CMA1 in human plasma

ChEMBL ↗

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Target

Chymase (CHEMBL4068) ↗

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Primary target Chymase

CHEMBL4068

Anchored from Assay target.

Protein identity Chymase

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Tissue	Plasma
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Chymase (CHEMBL4068) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Data for DCP probe BI-1942

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.70	6.70

Assay Parameters

Parameter	Type	Value	Units	Text
Additional information	Additional information	-	—	Reactive metabolite formation
Assay publication	Assay publication	-	—	PMID: 23659209
Target protein type	Target protein type	-	—	human plasma

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3640116	BI-1942	—	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3640116	BI-1942	IC50	=	198.0	nM	6.70