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Assay Detail

CHEMBL4888494

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Toxicity
Re-testing in dose-response curve in HepG2 cytotoxicity assay, at 72h
ChEMBL ↗
123
Total Activities
84
Compounds Tested
1
Activity Types
1
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum ,using a nano luciferase reporter read-out
Dechering K; Duffey M
(2022)
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 123 5.05 6.93

Assay Parameters

Parameter Type Value Units Text
TIMEPOINT TIMEPOINT 72.0 hour —

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4909580 — — 1 6.93
CHEMBL4979636 — — 1 5.75
CHEMBL4923196 — — 1 5.64
CHEMBL5019322 — — 1 5.54
CHEMBL5314060 — — 2 5.46
CHEMBL4897766 — — 1 5.46
CHEMBL5001025 — — 1 5.41
CHEMBL5310383 — — 2 5.39
CHEMBL5313643 — — 4 5.37
CHEMBL4930658 — — 1 5.32
CHEMBL5313303 — — 2 5.29
CHEMBL4924092 — — 1 5.27
CHEMBL5312290 — — 2 5.23
CHEMBL4903184 — — 1 5.21
CHEMBL5313534 — — 2 5.18
CHEMBL4909449 — — 1 5.13
CHEMBL5001249 — — 1 5.13
CHEMBL5310460 — — 2 5.10
CHEMBL5309024 — — 2 5.09
CHEMBL5313620 — — 4 5.05
CHEMBL5308631 — — 2 5.00
CHEMBL4949471 — — 1 4.99
CHEMBL4968838 — — 1 4.94
CHEMBL4929071 — — 1 4.90
CHEMBL4970694 — — 1 4.87
CHEMBL4984628 — — 1 4.83
CHEMBL4982236 — — 1 4.80
CHEMBL4970917 — — 1 4.79
CHEMBL5312330 — — 4 4.73
CHEMBL5312746 — — 2 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4909580 — IC50 = 118.0 nM 6.93
CHEMBL4979636 — IC50 = 1760.0 nM 5.75
CHEMBL4923196 — IC50 = 2270.0 nM 5.64
CHEMBL5019322 — IC50 = 2860.0 nM 5.54
CHEMBL4897766 — IC50 = 3480.0 nM 5.46
CHEMBL5314060 — IC50 = 3450.0 nM 5.46
CHEMBL5001025 — IC50 = 3900.0 nM 5.41
CHEMBL5314060 — IC50 = 4110.0 nM 5.39
CHEMBL5310383 — IC50 = 4100.0 nM 5.39
CHEMBL5313643 — IC50 = 4250.0 nM 5.37
CHEMBL5313643 — IC50 = 4250.0 nM 5.37
CHEMBL5310383 — IC50 = 4230.0 nM 5.37
CHEMBL4930658 — IC50 = 4750.0 nM 5.32
CHEMBL5313643 — IC50 = 5070.0 nM 5.29
CHEMBL5313643 — IC50 = 5070.0 nM 5.29
CHEMBL5313303 — IC50 = 5110.0 nM 5.29
CHEMBL4924092 — IC50 = 5420.0 nM 5.27
CHEMBL5312290 — IC50 = 5930.0 nM 5.23
CHEMBL5313303 — IC50 = 5840.0 nM 5.23
CHEMBL4903184 — IC50 = 6110.0 nM 5.21
CHEMBL5313534 — IC50 = 6650.0 nM 5.18
CHEMBL5313534 — IC50 = 6940.0 nM 5.16
CHEMBL5312290 — IC50 = 7030.0 nM 5.15
CHEMBL5001249 — IC50 = 7350.0 nM 5.13
CHEMBL4909449 — IC50 = 7420.0 nM 5.13
CHEMBL5310460 — IC50 = 7920.0 nM 5.10
CHEMBL5309024 — IC50 = 8180.0 nM 5.09
CHEMBL5313620 — IC50 = 8910.0 nM 5.05
CHEMBL5313620 — IC50 = 8910.0 nM 5.05
CHEMBL5313620 — IC50 = 9280.0 nM 5.03
CHEMBL5313620 — IC50 = 9280.0 nM 5.03
CHEMBL5309024 — IC50 = 9550.0 nM 5.02
CHEMBL5308631 — IC50 = 10000.0 nM 5.00
CHEMBL5308631 — IC50 = 10300.0 nM 4.99
CHEMBL4949471 — IC50 = 10200.0 nM 4.99
CHEMBL5310460 — IC50 = 11000.0 nM 4.96
CHEMBL4968838 — IC50 = 11400.0 nM 4.94
CHEMBL4929071 — IC50 = 12500.0 nM 4.90
CHEMBL4970694 — IC50 = 13600.0 nM 4.87
CHEMBL4984628 — IC50 = 14900.0 nM 4.83
CHEMBL4982236 — IC50 = 15900.0 nM 4.80
CHEMBL4970917 — IC50 = 16300.0 nM 4.79
CHEMBL5312330 — IC50 = 18700.0 nM 4.73
CHEMBL5312746 — IC50 = 19200.0 nM 4.72
CHEMBL5312746 — IC50 = 19000.0 nM 4.72
CHEMBL4977924 — IC50 = 19400.0 nM 4.71
CHEMBL5311772 — IC50 = 19900.0 nM 4.70
CHEMBL5311772 — IC50 = 20200.0 nM 4.70
CHEMBL5312669 — IC50 = 20100.0 nM 4.70
CHEMBL5311484 — IC50 = 20300.0 nM 4.69