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Assay Detail

CHEMBL5029280

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mammalian Alpha-glucosidase (unknown origin) using PNPG as substrate pretreated for 20 mins followed by substrate addition measured after 26 mins
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide-deoxynojirimycin Conjugates.
Li RF, Yang JX, Liu J, Ai GM, Zhang HY, Xu LY, Chen SB, Zhang HX, Li XL, Cao ZR, Wang KR.
J Med Chem (2021) 64 : 5863 -5873
PubMed 33886333 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Inhibition 2 - -
IC50 2 4.89 4.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5078012 2 4.93
CHEMBL5090920 2 4.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5078012 IC50 = 11610.0 nM 4.93
CHEMBL5090920 IC50 = 14420.0 nM 4.84
CHEMBL5078012 Inhibition - % -
CHEMBL5090920 Inhibition - % -