Assay Detail
Functional
CHEMBL5029397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human OX2R stably expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-RD-HGA16 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075103 | — | — | 1 | 9.00 |
| CHEMBL5091326 | — | — | 1 | 8.28 |
| CHEMBL4650341 | DANAVOREXTON | 2.0 | 1 | 5.26 |
| CHEMBL1198149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075103 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5091326 | — | EC50 | = | 5.248 | nM | 8.28 |
| CHEMBL4650341 | DANAVOREXTON | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1198149 | — | EC50 | > | 3200.0 | nM | - |