Assay Detail
Binding
CHEMBL5029450
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Binding affinity to human CREBBP bromodomain expressed in Escherichia coli BL21 (DE3)-RIL
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.62 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089448 | — | — | 1 | 7.00 |
| CHEMBL5085843 | — | — | 1 | 6.80 |
| CHEMBL5085444 | — | — | 1 | 6.50 |
| CHEMBL3752296 | — | — | 1 | 6.50 |
| CHEMBL5076790 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089448 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL5085843 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL5085444 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL3752296 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL5076790 | — | Kd | = | 501.19 | nM | 6.30 |