Assay Detail
Functional
CHEMBL5029668
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Cytotoxicity against human A549 cells assessed as reduction in cell viability
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.99 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.80 |
| CHEMBL5081949 | — | — | 1 | 6.43 |
| CHEMBL5078714 | — | — | 1 | 6.37 |
| CHEMBL5083241 | — | — | 1 | 6.26 |
| CHEMBL5076806 | — | — | 1 | 6.20 |
| CHEMBL5082373 | — | — | 1 | 6.11 |
| CHEMBL5082970 | — | — | 1 | 6.11 |
| CHEMBL5080174 | — | — | 1 | 5.72 |
| CHEMBL5078829 | — | — | 1 | 5.68 |
| CHEMBL5080222 | — | — | 1 | 5.64 |
| CHEMBL5084453 | — | — | 1 | 5.55 |
| CHEMBL5084265 | — | — | 1 | 5.47 |
| CHEMBL5089667 | — | — | 1 | 5.28 |
| CHEMBL5082339 | — | — | 1 | 5.22 |
| CHEMBL5084201 | — | — | 1 | - |
| CHEMBL5085247 | — | — | 1 | - |
| CHEMBL5080773 | — | — | 1 | - |
| CHEMBL5088884 | — | — | 1 | - |
| CHEMBL5086938 | — | — | 1 | - |
| CHEMBL5076072 | — | — | 1 | - |
| CHEMBL5091332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5081949 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5078714 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5083241 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5076806 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5082373 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5082970 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5080174 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5078829 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5080222 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5084453 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5084265 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5089667 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5082339 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5084201 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5085247 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5080773 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5088884 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5086938 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5076072 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091332 | — | IC50 | > | 10000.0 | nM | - |