Assay Detail
Functional
CHEMBL5029686
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Down modulation of sortilin expression in HEK293T cells tranfected with GFP-tagged sortilin incubated for 24 hrs by flow cytometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.88 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089500 | — | — | 1 | 7.00 |
| CHEMBL1819187 | — | — | 1 | 6.30 |
| CHEMBL5086848 | — | — | 1 | 6.00 |
| CHEMBL5092871 | — | — | 1 | 5.72 |
| CHEMBL1819181 | CYCLOTRIAZADISULFONAMIDE HYDROCHLORIDE | — | 1 | 5.66 |
| CHEMBL4748787 | — | — | 1 | 5.40 |
| CHEMBL5081066 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089500 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1819187 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5086848 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5092871 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1819181 | CYCLOTRIAZADISULFONAMIDE HYDROCHLORIDE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4748787 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5081066 | — | IC50 | = | 9000.0 | nM | 5.05 |