Assay Detail
Binding
CHEMBL5029740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.48 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093088 | — | — | 1 | 9.40 |
| CHEMBL5075689 | — | — | 1 | 9.03 |
| CHEMBL5091877 | — | — | 1 | 8.85 |
| CHEMBL5081571 | — | — | 1 | 8.70 |
| CHEMBL5074678 | — | — | 1 | 8.64 |
| CHEMBL5084928 | — | — | 1 | 8.64 |
| CHEMBL5092328 | — | — | 1 | 8.57 |
| CHEMBL5074719 | — | — | 1 | 8.52 |
| CHEMBL4465534 | — | — | 1 | 8.42 |
| CHEMBL5090362 | — | — | 1 | 8.41 |
| CHEMBL5083750 | — | — | 1 | 8.40 |
| CHEMBL5082356 | — | — | 1 | 8.02 |
| CHEMBL5088971 | — | — | 1 | 8.00 |
| CHEMBL5089679 | — | — | 1 | 8.00 |
| CHEMBL5075795 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093088 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5075689 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL5091877 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5081571 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5074678 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5084928 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5092328 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5074719 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4465534 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5090362 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5083750 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5082356 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL5088971 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5089679 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5075795 | — | IC50 | = | 28.0 | nM | 7.55 |