Assay Detail
Functional
CHEMBL5029807
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Antiproliferative activity against human JJN-3R cells assessed as reduction in cell viability
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JJN-3R |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.02 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089688 | — | — | 1 | 8.74 |
| CHEMBL5075294 | — | — | 1 | 8.62 |
| CHEMBL4297458 | EZOBRESIB | 2.0 | 1 | 8.44 |
| CHEMBL5084636 | — | — | 1 | 8.35 |
| CHEMBL5084198 | — | — | 1 | 8.28 |
| CHEMBL5086429 | — | — | 1 | 8.21 |
| CHEMBL5091333 | — | — | 1 | 8.12 |
| CHEMBL5090513 | — | — | 1 | 7.92 |
| CHEMBL5080039 | — | — | 1 | 7.66 |
| CHEMBL5090808 | — | — | 1 | 7.29 |
| CHEMBL5069754 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089688 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5075294 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4297458 | EZOBRESIB | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5084636 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5084198 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5086429 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5091333 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5090513 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5080039 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5090808 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5069754 | — | IC50 | = | 260.0 | nM | 6.58 |