Assay Detail
Functional
CHEMBL5030197
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Inhibition of electric-field induced mouse vas deferens contraction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Cyclic Endomorphin Analogues with Multiple Modifications and Oligoarginine Vector Exhibit Potent Antinociception with Reduced Opioid-like Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.13 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 7.37 |
| CHEMBL5076581 | — | — | 1 | 7.32 |
| CHEMBL5085104 | — | — | 1 | 7.31 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 7.30 |
| CHEMBL5080666 | — | — | 1 | 7.01 |
| CHEMBL5084034 | — | — | 1 | 6.97 |
| CHEMBL5080233 | — | — | 1 | 6.86 |
| CHEMBL5078349 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 42.9 | nM | 7.37 |
| CHEMBL5076581 | — | IC50 | = | 47.5 | nM | 7.32 |
| CHEMBL5085104 | — | IC50 | = | 49.3 | nM | 7.31 |
| CHEMBL316446 | ENDOMORPHIN-1 | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL5080666 | — | IC50 | = | 97.5 | nM | 7.01 |
| CHEMBL5084034 | — | IC50 | = | 107.5 | nM | 6.97 |
| CHEMBL5080233 | — | IC50 | = | 137.8 | nM | 6.86 |
| CHEMBL5078349 | — | IC50 | = | 139.0 | nM | 6.86 |