Assay Detail
Binding
CHEMBL5030258
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Inhibition of SARS-Cov2 N-terminal full-length MBP-tagged 3CL protease expressed in Escherichia coli using DABCYL-KTSAVLQSGFRKME-EDANS as substrate preincubated for 30 mins followed by substrate addition and measured after 3 hrs by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.43 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275311 | — | — | 1 | 4.45 |
| CHEMBL2386114 | — | — | 1 | 4.45 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.40 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275311 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL2386114 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 39800.0 | nM | 4.40 |