Assay Detail
Functional
CHEMBL5030441
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Induction of IFN-gamma production in human Vgamma9Vdelta2-T cells incubated for 240 mins with compound-loaded K562 cells followed by compound washout and measured after 20 hrs by ELISA
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Vgamma9Vdelta2-T cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Metabolism of BTN3A1 Ligands: Studies on Diene Modifications to the Phosphoantigen Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.15 | 7.62 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088948 | — | — | 1 | 7.62 |
| CHEMBL5074923 | — | — | 1 | 5.04 |
| CHEMBL5092970 | — | — | 1 | 4.96 |
| CHEMBL5085361 | — | — | 1 | 4.75 |
| CHEMBL5084726 | — | — | 1 | 4.42 |
| CHEMBL5087983 | — | — | 1 | 4.12 |
| CHEMBL5081999 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088948 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5074923 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5092970 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5085361 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5084726 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5087983 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL5081999 | — | Activity | - | — | - |