Assay Detail
Functional
CHEMBL5030899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells harboring KRAS mutant assessed as reduction in cell viability incubated for 24 hrs by Click-iT EdU cell proliferation imaging assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.88 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094268 | — | — | 1 | 6.28 |
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 6.26 |
| CHEMBL5090624 | — | — | 1 | 6.01 |
| CHEMBL5079215 | — | — | 1 | 5.85 |
| CHEMBL5094514 | — | — | 1 | 5.62 |
| CHEMBL5075174 | — | — | 1 | 5.57 |
| CHEMBL4780060 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094268 | — | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL3577124 | LY-3009120 | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL5090624 | — | IC50 | = | 986.0 | nM | 6.01 |
| CHEMBL5079215 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5094514 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5075174 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4780060 | — | IC50 | = | 2900.0 | nM | 5.54 |