Assay Detail
Functional
CHEMBL5030941
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs in presence of 5 mM GSH by SRB assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-Fluorouracil.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.75 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083074 | — | — | 1 | 5.42 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.28 |
| CHEMBL5084141 | — | — | 1 | 5.10 |
| CHEMBL5077765 | — | — | 1 | 4.62 |
| CHEMBL5081736 | — | — | 1 | 4.06 |
| CHEMBL5086704 | — | — | 1 | 4.03 |
| CHEMBL5094407 | — | — | 1 | - |
| CHEMBL5078094 | — | — | 1 | - |
| CHEMBL5077737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083074 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5084141 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5077765 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL5081736 | — | IC50 | = | 86900.0 | nM | 4.06 |
| CHEMBL5086704 | — | IC50 | = | 93600.0 | nM | 4.03 |
| CHEMBL5094407 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078094 | — | IC50 | - | — | - | |
| CHEMBL5077737 | — | IC50 | - | — | - |