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Assay Detail

CHEMBL5031172

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition beta lactamase PDC-1 in Pseudomonas aeruginosa PAO1 using nitrocefin as substrate measured by 96 well microtitre plate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pseudomonas aeruginosa PAO1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

6-Halopyridylmethylidene Penicillin-Based Sulfones Efficiently Inactivate the Natural Resistance of <i>Pseudomonas aeruginosa</i> to β-Lactam Antibiotics.
Vázquez-Ucha JC, Rodríguez D, Lasarte-Monterrubio C, Lence E, Arca-Suarez J, Maneiro M, Gato E, Perez A, Martínez-Guitián M, Juan C, Oliver A, Bou G, González-Bello C, Beceiro A.
J Med Chem (2021) 64 : 6310 -6328
PubMed 33913328 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 7.36 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4476316 1 9.05
CHEMBL1257120 1 8.21
CHEMBL4475789 1 8.20
CHEMBL2107817 AVIBACTAM SODIUM 4.0 1 7.29
CHEMBL404 TAZOBACTAM 4.0 1 6.07
CHEMBL403 SULBACTAM 4.0 1 5.36
CHEMBL777 CLAVULANIC ACID 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4476316 IC50 = 0.9 nM 9.05
CHEMBL1257120 IC50 = 6.1 nM 8.21
CHEMBL4475789 IC50 = 6.3 nM 8.20
CHEMBL2107817 AVIBACTAM SODIUM IC50 = 51.0 nM 7.29
CHEMBL404 TAZOBACTAM IC50 = 844.4 nM 6.07
CHEMBL403 SULBACTAM IC50 = 4369.6 nM 5.36
CHEMBL777 CLAVULANIC ACID IC50 > 200000.0 nM -