Assay Detail
Binding
CHEMBL5031442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 to 20 mins by Ellman's method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.97 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5092811 | — | — | 1 | 7.05 |
| CHEMBL5082961 | — | — | 1 | 6.96 |
| CHEMBL5087317 | — | — | 1 | 6.62 |
| CHEMBL5081935 | — | — | 1 | 6.57 |
| CHEMBL5081383 | — | — | 1 | 6.43 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.32 |
| CHEMBL5081762 | — | — | 1 | 6.26 |
| CHEMBL5076807 | — | — | 1 | 6.20 |
| CHEMBL5077537 | — | — | 1 | 6.14 |
| CHEMBL5079923 | — | — | 1 | 6.11 |
| CHEMBL5090337 | — | — | 1 | 6.09 |
| CHEMBL5081143 | — | — | 1 | 6.04 |
| CHEMBL5081943 | — | — | 1 | 6.03 |
| CHEMBL5079083 | — | — | 1 | 6.00 |
| CHEMBL5088203 | — | — | 1 | 6.00 |
| CHEMBL5078942 | — | — | 1 | 5.98 |
| CHEMBL5089282 | — | — | 1 | 5.95 |
| CHEMBL5091149 | — | — | 1 | 5.93 |
| CHEMBL5074820 | — | — | 1 | 5.93 |
| CHEMBL5083618 | — | — | 1 | 5.90 |
| CHEMBL5080963 | — | — | 1 | 5.88 |
| CHEMBL5087641 | — | — | 1 | 5.83 |
| CHEMBL5075963 | — | — | 1 | 5.82 |
| CHEMBL5093283 | — | — | 1 | 5.74 |
| CHEMBL5083124 | — | — | 1 | 5.72 |
| CHEMBL5080653 | — | — | 1 | 5.70 |
| CHEMBL5084218 | — | — | 1 | 5.67 |
| CHEMBL5077897 | — | — | 1 | 5.67 |
| CHEMBL5080631 | — | — | 1 | 5.62 |
| CHEMBL5088826 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5092811 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5082961 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5087317 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5081935 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5081383 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5081762 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5076807 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5077537 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5079923 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5090337 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5081143 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5081943 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5079083 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5088203 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5078942 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL5089282 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5091149 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5074820 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5083618 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5080963 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL5087641 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5075963 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5093283 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5083124 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL5080653 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL5084218 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL5077897 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5080631 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL5088826 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL5072304 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL5085264 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL5081362 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL252642 | LIQUIRTIGENIN | IC50 | = | 9100.0 | nM | 5.04 |