Assay Detail
Functional
CHEMBL5031571
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Anti-Breast-Cancer Inhibitors by Synergistically Antagonizing Microtubule Polymerization and Aryl Hydrocarbon Receptor Expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.79 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5072012 | — | — | 1 | 9.05 |
| CHEMBL5079976 | — | — | 1 | 8.68 |
| CHEMBL5092123 | — | — | 1 | 8.62 |
| CHEMBL5077318 | — | — | 1 | 8.35 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.32 |
| CHEMBL5091252 | — | — | 1 | 7.60 |
| CHEMBL5088037 | — | — | 1 | 7.27 |
| CHEMBL5092856 | — | — | 1 | 7.01 |
| CHEMBL5084709 | — | — | 1 | 6.99 |
| CHEMBL5091561 | — | — | 1 | 6.03 |
| CHEMBL5074604 | — | — | 1 | - |
| CHEMBL5090768 | — | — | 1 | - |
| CHEMBL5086641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5072012 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5079976 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5092123 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5077318 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5091252 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5088037 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5092856 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5084709 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5091561 | — | IC50 | = | 943.0 | nM | 6.03 |
| CHEMBL5074604 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5090768 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5086641 | — | IC50 | > | 1000.0 | nM | - |