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Assay Detail

CHEMBL5031574

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Antiproliferative activity against human L-O2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type L02
Confidence 1 — Organism
Curated By Autocuration

Target

L02 (CHEMBL4296457)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of Novel Anti-Breast-Cancer Inhibitors by Synergistically Antagonizing Microtubule Polymerization and Aryl Hydrocarbon Receptor Expression.
Wang K, Zhong H, Li N, Yu N, Wang Y, Chen L, Sun J.
J Med Chem (2021) 64 : 12964 -12977
PubMed 34428056 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.78 8.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5072012 1 8.34
CHEMBL5092123 1 8.14
CHEMBL5079976 1 8.14
CHEMBL5077318 1 8.00
CHEMBL67 COMBRETASTATIN A4 -1.0 1 7.99
CHEMBL5091252 1 7.51
CHEMBL5091561 1 6.64
CHEMBL5084709 1 5.82
CHEMBL5092856 1 5.66
CHEMBL5088037 1 5.60
CHEMBL5086641 1 5.46
CHEMBL5090768 1 5.42
CHEMBL5074604 1 5.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5072012 IC50 = 4.6 nM 8.34
CHEMBL5092123 IC50 = 7.3 nM 8.14
CHEMBL5079976 IC50 = 7.3 nM 8.14
CHEMBL5077318 IC50 = 10.0 nM 8.00
CHEMBL67 COMBRETASTATIN A4 IC50 = 10.3 nM 7.99
CHEMBL5091252 IC50 = 31.0 nM 7.51
CHEMBL5091561 IC50 = 227.0 nM 6.64
CHEMBL5084709 IC50 = 1527.0 nM 5.82
CHEMBL5092856 IC50 = 2173.0 nM 5.66
CHEMBL5088037 IC50 = 2497.0 nM 5.60
CHEMBL5086641 IC50 = 3447.0 nM 5.46
CHEMBL5090768 IC50 = 3839.0 nM 5.42
CHEMBL5074604 IC50 = 4121.0 nM 5.38