Assay Detail
Binding
CHEMBL5031648
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Inhibition of ALDH1A1 in human drug-tolerant MDA-MB-231/lapatinib cells assessed as after 24 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.65 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094282 | — | — | 1 | 7.06 |
| CHEMBL5079998 | — | — | 1 | 6.87 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 6.37 |
| CHEMBL567 | PERPHENAZINE | 4.0 | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094282 | — | IC50 | = | 86.42 | nM | 7.06 |
| CHEMBL5079998 | — | IC50 | = | 134.58 | nM | 6.87 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 425.32 | nM | 6.37 |
| CHEMBL567 | PERPHENAZINE | IC50 | = | 524.21 | nM | 6.28 |