Assay Detail
Functional
CHEMBL5031745
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Antiproliferative activity against VEGF-A stimulated human retinal endothelial cell assessed as reduction in cell viability measured after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HREC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Haloperidol Metabolite II Valproate Ester (<i>S</i>)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.05 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.58 |
| CHEMBL5094340 | — | — | 1 | 5.36 |
| CHEMBL5079556 | — | — | 1 | 5.17 |
| CHEMBL4747257 | — | — | 1 | 5.00 |
| CHEMBL1036 | HYDROXYHALOPERIDOL | — | 1 | 4.16 |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5094340 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5079556 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4747257 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1036 | HYDROXYHALOPERIDOL | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 1393000.0 | nM | - |