Assay Detail
Binding
CHEMBL5031856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 in human SKNBE2 cells expressing wildtype APP assessed as reduction in amyloid beta 42 level incubated for 18 hrs by sandwich AlphaLISA assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SKNBE2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4557670 | — | — | 1 | 9.00 |
| CHEMBL5093159 | — | — | 1 | 8.96 |
| CHEMBL5075689 | — | — | 1 | 8.64 |
| CHEMBL5079271 | — | — | 1 | 7.54 |
| CHEMBL5072129 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4557670 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5093159 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5075689 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5079271 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5072129 | — | IC50 | = | 123.0 | nM | 6.91 |